why not make it all on one on text event like this

ON *:TEXT:*:#:{ 
  if ($strip($1) == !number) { 
    if (!$($+(%,number,$chan),2)) {
      set $+(%,number,$chan) $r(1,100) 
      msg $chan I Have Choosen A Random Number Between: 1 And 100 To Guess What It Is Type: !guess <number> 
    } 
    elseif (!$($+(%,$chan,$nick,yesgame),2)) { msg $chan Game already in progress. Please Type " !guess 1-100 " to play. | set -u5 $+(%,$chan,$nick,yesgame) $nick }
  }
  if ($strip($1) == !guess) && (!$($+(%,flood,$chan),2)) { 
    set -u3 $+(%,flood,$chan) $nick
    if ($($+(%,number,$chan),2)) {
      if (!$2) || ($2 !isnum 1-100) { msg $chan Please pick a number 1-100 ex: !guess 34 }
      elseif ($2 == $($+(%,number,$chan),2)) { msg # WOW nice job!! $nick The Number Was $2 | unset $+(%,number,$chan) }  
      else { msg # $iif($2 < $($+(%,number,$chan),2),It's Higher Than $2,It's Lower Than $2) }
    }
    elseif (!$($+(%,$chan,$nick,nogame),2)) { msg $chan No Game in progress. Please Type " !number " to start a game. | set -u10 $+(%,$chan,$nick,nogame) $nick }
  }
}