I made this originally for myself because I wanted a VERY simple way of blocking pm's when I didn't want to get any. Thanks to Daveoh for reminding me to add the ^ to my on event.

Edit: I added an allow list to it. Tell me what you think.

Edit: I added an on exit event to set your dnd off when you shut down mIRC.

DND System
.Turn On/Off
..On:set %dnd on | amsg [ DND is ON ][ I am not accepting P2P's ]
..Off:set %dnd off | amsg [ DND is OFF ][ I am now accepting P2P's ]
.DND Allow List
..Add User:auser dndallow $$1
..Del User:ruser dndallow $$1

-
Add the above section to your POPUPS (Alt+P)
-
on ^*:OPEN:?:*: {
  if ($ulevel == dndallow) { return }
  elseif (%dnd == on) {
    .msg $nick 14,1[ 3,1DND 0,1is 3,1ON 14,1][0,1 I am not accepting 3,1P2P's 14,1]
    halt
  }
}
on *:EXIT: {
  if (%dnd == on) {
    set %dnd off
  }
}
-
Add the above section to your REMOTES (Alt+R)