If there are any die hard emule users left out there, this section of code comes in handy.

on ^$*:Hotlink:/^(ed2k\:\/\/\|.*\|\/)$/Si:#:{
  if ($mouse.key == 16) && ($input(Do you wish to open this Ed2K Link ?,yn)) { run $regml(1) }
  halt
}

This will allow you to right click a ED2K link and open it from the mIRC channel window.
Put this code in your main client.