on *:text:*:*: {
  if ($istok(%text.1 %text.2,$1,32)) { msg $chan $gettok(%reply.1 %reply.2 %reply.3 %reply.4,$r(1,4),32) }
} 

I don't see where that'd look for my variable %randomreply.

on *:text:*:*: {
  set %randomreply $r(1,4)

I am trying to use that to reply depending on what the $r(1,4) sets, not just randomly reply with one of my four %reply.N's.