no need to check if $nick isop on every command, and you should make sure that the bot or who ever is running this code has op in the channel.

you also dont have to use $strip in every command line you can use tokenize 32 $strip($1-).

on @*:TEXT:*:#: {
  tokenize 32 $strip($1-)
  if ($nick(#,$nick,o) && !$($+(%,opc,.,Commandflood,.,$nick),2)) { 
    set -u3 $+(%,opc,.,Commandflood,.,$nick) on
    if ($1 == !opc) { .notice $nick Op commands are: !ban < username >, !unban < username >, !kick < username >, +m, -m, +i, -i, +v < username >, -v < username >, +o < username >, -o < username > and !topic. Note: These commands only work for ops and if I am oped. }
    if ($1 == !topic && $2) { topic # $2- }
    if ($1 == !kick && $2 ison # && $2 != $me) { kick # $2 $iif(!$3,No Reason,$3-) | .notice $2 You where kicked by: $nick at $time on $date for $+($iif(!$3,No Reason,$3-),.) }
    if ($regex($1,/^\!(ban|unban)$/) && $2 ison # && $2 != $me) { mode # $iif($1 == !ban,+b,-b) $address($2,2) }
    if ($regex($1,/^[+-][ov]$/)) { mode # $1 $iif(!$2,$nick,$2) }
    if ($regex($1,/^[+-][im]/)) { mode # $1 }
  }
  elseif ($istok(!ban !unban !topic !kick +o +v +m +i -i -m -v -o !opc,$1,32) && !$nick(#,$nick,o) && !$($+(%,opcflood,.,$nick),2)) { set -u3 $+(%,opcflood,.,$nick) on | .notice $nick You must be an OP to use these commands. }
}

but as ur code is 4/10