You can combine some of these if statements. Example:

if ($nick isop $chan || $nick ishop $chan) {
  notice $2 you now have a strike...
  notice $nick you have issued a strike...
}

And then with

  if (%strike. [ $+ [ $2- ] ] == 3) notice $nick $2- has 3 strikes, which is kbable, so go ahead
  if (%strike. [ $+ [ $2- ] ] == 3) set %strike. [ $+ [ $2- ] ] 

You can combine them:

  if (%strike. [ $+ [ $2- ] ] == 3) {
    notice $nick $2- has 3 strikes, which is kbable, so go ahead
    set %strike. [ $+ [ $2- ] ] 
  }

Just use brackets { } and you can put multiple things in one if statement.