What the hell is $($+(,,,*)) for? If you\'re wanting to match everything a single wildcard will suffice.
In your comment you say it will open a notice window, this must be something specific to the script that you are using. mIRC doesn\'t have that built in, you would have to do it in the script.
And instead of making more identical events for it to work for multiple users, you can use $istok.
For example
var %nicks = Nick1 Nick2 NickN
if ($istok(%nicks,$nick,32)) { ...